Check out our Instagram, Facebook, YouTube, and Twitter!

Merkel cell carcinoma


 

Merkel cell carcinoma: This rare skin cancer can appear on the skin as a hard patch (1) or firm bump (2).

Merkel cell carcinoma: Overview

What is Merkel cell carcinoma?

Merkel cell carcinoma (MCC) is a rare skin cancer. It is also an aggressive skin cancer. MCC is considered aggressive because it can:

  • Grow quickly and spread.
  • Return after treatment.


Because MCC is aggressive, doctors recommend prompt treatment. The sooner this skin cancer is treated the better the outcome. To improve a patient’s outcome, a team of doctors usually creates the treatment plan for MCC. This approach allows the patient to benefit from the expertise of specialists in different areas of medicine. The team often includes a dermatologist, a medical oncologist (cancer specialist), and a radiation oncologist (specialist in treating cancer with radiation.) Other doctors may also be a part of this team.

It is important for patients diagnosed with MCC to:

  • Keep all appointments with their doctors.
  • Check their skin and lymph nodes for signs of cancer as recommended.


These actions help find cancer as early as possible.

Images used with permission of Journal of the American Academy of Dermatology: J Am Acad Dermatol. 2012; 66:923-7


References:
Harting MS, Ludgate MW, Fullen DR et al. “Dermatoscopic vascular patterns in cutaneous Merkel cell carcinoma,” J Am Acad Dermatol 2012; 66(6): pages 923-7.
Heath M, Jaimes N, Lemos BD et al. “Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.” J Am Acad Dermatol 2008; 58:375-81.
Lemos BD, Storer BE, Iyer JG et al. “Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.” J Am Acad Dermatol 2010; 63:751-61.
Nghiem P, Jaimes N. “Merkel Cell Carcinoma.” In: Wolff K, Goldsmith LA, Katz SI, et al. editors. Fitzpatrick’s Dermatology in General Medicine, 7th ed. United States of America, McGraw Hill Medical; 2008. p. 1087-94.


Merkel cell carcinoma: This rare skin cancer most commonly looks like a shiny, dome-shaped growth that has visible blood vessels.

Merkel cell carcinoma: Signs and symptoms

This rare skin cancer often looks harmless. Many people mistake it for a pimple, bug bite, or cyst. If you see a lump or hardened patch on your skin that looks like any pictures on this page, you should immediately make an appointment to see a dermatologist.

This appointment is especially important if you have:

  • Fair skin and are 50 years of age or older.
  • A disease that weakens your immune system, such as HIV or chronic lymphocytic leukemia (a cancer of the blood and bone marrow).
  • Received an organ transplant.
  • Had Merkel cell carcinoma (MCC) or another skin cancer.


Merkel cell carcinoma: What it looks like

MCC often appears on skin that has had lots of sun exposure. The MCC tumor tends to:

  • Feel firm.
  • Grow quickly (in a few weeks or months).
  • Have one color, either red, pink, blue, or violet.


MCC also can appear as a rough, hardened patch of skin. This patch tends to form on the trunk of the body.

Merkel cell carcinoma: Symptoms

People diagnosed with MCC often say that the lump or patch was painless.

Merkel cell carcinoma: Where it appears on the body

This rare skin cancer can develop anywhere on the skin. Most MCCs, however, appear on skin that has received lots of sun exposure. About half of MCCs develop on the head or neck, with many of these forming on the eyelid. Other places that MCC tends to develop are the legs, arms, feet, buttocks, and genitals.

One of the greatest risk factors for MCC is age. Most MCCs develop in people who are 50 years of age or older. Other risk factors for MCC also increase the likelihood of developing this rare skin cancer.

Images used with permission of Journal of the American Academy of Dermatology: 1 J Am Acad Dermatol. 2011; 65:983-90


References:
Akhtar S, Oza KK, Wright J. “Merkel cell carcinoma: report of 10 cases and review of the literature.” J Am Acad Dermatol 2000 Nov; 43(5 Pt 1):755-67.
Becker JC. “Merkel cell carcinoma.” Ann Oncol 2010; 21(suppl 7)vii81-5.
Gao L. “Merkel cell carcinoma: Tips and advancements in management.” Educational session presented at the 2013 American Academy of Dermatology Annual Meeting: Miami. Mar 2013.
Heath M, Jaimes N, Lemos BD, et al. “Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.” J Am Acad Dermatol 2008; 58:375-81.
Pape E, Rezvov N, Penel N, et al. “Radiotherapy alone for Merkel cell carcinoma: a comparative and retrospective study of 25 patients.” J Am Acad Dermatol 2011; 65:983-90.


Merkel cell carcinoma: Who gets and causes

Who gets Merkel cell carcinoma?

Most Merkel cell cancers are diagnosed in people who are:

  • 50 years of age or older (90%).
  • Fair skinned and did not protect their skin from the sun (98%).


According to research studies, gender also seems to play a role. Men are twice as likely to get to MCC.

Other risk factors

Anything that increases your risk of getting a disease is a risk factor. Age, fair skin, and lots of sun exposure are the most common risk factors for MCC. Other risk factors for MCC are: 

Illness that weakens your immune system: Your immune system helps you stay healthy. Some illnesses, however, weaken your immune system. Illnesses that weaken the immune system include HIV and chronic lymphocytic leukemia (a cancer of the blood and bone marrow).

Medicine that weakens your immune system: People who received an organ transplant must take medicine for life. This medicine prevents the body from rejecting the transplanted organ. It also weakens the immune system. Other medicines can also weaken the immune system.

Exposure to arsenic or infrared light: Being exposed to arsenic for a long time seems to increase the risk. Long-term exposure can come from drinking well water that contains arsenic. Some people are exposed to arsenic in the workplace. Infrared light is common in some workplaces and homes. Common sources of infrared light are lasers, some furnaces, and heat lamps.

PUVA therapy, using methoxsalen (meth-OX-a-len): Some patients treated with PUVA therapy receive a medicine called methoxsalen. In one study, researchers found that 3 of the 1,380 patients taking methoxsalen developed MCC. The cancer developed many years later. All of the patients had taken methoxsalen during their PUVA therapy. Two of these patients received more than 300 PUVA treatments.

What causes Merkel cell carcinoma?

Scientists are still studying what causes this skin cancer.

A research breakthrough came in 2008 when scientists discovered a virus called the Merkel cell polyomavirus. This virus is found in many Merkel cell tumors. To gain a better understanding of this cancer, scientists are studying this virus.

If you have risk factors for Merkel cell carcinoma

Having risk factors does not mean that you will get MCC. This skin cancer is rare. You can reduce your risk by protecting your skin from the sun. This can also reduce your risk for getting other types of skin cancer.

If you are concerned that you may have MCC, you should immediately make an appointment to see a dermatologist.


References:
Bichakjian CK, Alam M, Andersen J, et al. “Merkel cell carcinoma: Clinical practice guidelines in oncology.” National Comprehensive Cancer Network. Version 2.2013.
Feng H, Shuda M, Chang Y, et al. “Clonal integration of a polyomavirus in human Merkel cell carcinoma.” Science 2008; 319:1096-100.
Heath M, Jaimes N, Lemos BD, et al. “Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.” J Am Acad Dermatol 2008; 58:375-81.
Lemos BD, Storer BE, Iyer JG, et al. “Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.” J Am Acad Dermatol 2010; 63:751-61.
Lunder EJ, Stern RS, “Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation.” (Letters to the editor). N Engl J Med. 1998; 339:1247-8.
Reisinger DM, Shiffer JD, Cognetta AB, et al. “Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma.” J Am Acad Dermatol 2010; 63:400-3


Merkel cell carcinoma: Diagnosis and treatment

How is Merkel cell carcinoma diagnosed?

Diagnosis begins with an exam. Your dermatologist (or other doctor) will closely examine your skin and lymph nodes. We have lymph nodes in our neck, underarms, and other areas of the body. Lymph nodes help to protect us from illness. They often swell when we are sick.

If your doctor suspects Merkel cell carcinoma (MCC), you will need a skin biopsy. This is the only way to diagnose skin cancer. Your dermatologist can safely perform a skin biopsy during an office visit. To perform a skin biopsy, a dermatologist removes either the entire tumor or part of it.

What your dermatologist removes will be examined under a microscope. This magnified view allows a doctor to look for cancer cells.

How is Merkel cell carcinoma treated?

When the diagnosis is MCC, doctors with experience treating this rare skin cancer should be consulted. Each of these doctors should have expertise in a different field of medicine, such as dermatology, surgery, oncology, and radiation oncology. Working together, these doctors can create a treatment plan.

Before the doctors create a treatment plan, they want to find the stage of the cancer. Treatment differs for each stage. The stage tells doctors how deep the MCC has grown and whether the cancer has spread.

Finding the stage: To find the stage, a patient undergoes a process called staging. Staging for MCC often begins with an imaging test, such as a PET/CT scan. This allows the doctors to see if cancer has spread to organs inside the body.

After imaging tests, many patients diagnosed with MCC have a surgical procedure called a sentinel lymph node biopsy (SLNB). A SLNB can tell doctors if the cancer has spread to a patient’s lymph nodes. When MCC begins to spread, it often travels to a certain lymph node first. A SLNB can tell doctors to which lymph node the cancer would travel first and whether that lymph node or nearby lymph nodes contain cancer cells.

What happens during a SLNB

For many patients, a SLNB is an outpatient procedure. In some cases, getting a SLNB requires a short hospital stay. During this surgery, the following happens:

  1. The surgeon injects a dye, radioactive substance, or both into the patient. The injection is made near the MCC tumor.
  2. The surgeon uses a special device to follow the injected substance, which travels to the sentinel node (first node to which the cancer is likely to spread).
  3. The surgeon makes a small incision and removes the sentinel lymph node, and in some cases, other lymph nodes.
  4. A specially trained doctor, a pathologist, checks the removed lymph node(s) for cancer.
  5. If the pathologist finds cancer, the surgeon may remove more lymph nodes. Sometimes, the surgeon can do this during the same surgery. Sometimes, the patient needs a second surgery.


After finding and removing the lymph node(s), the surgeon may remove the Merkel cell tumor. Sometimes, removing the tumor requires another surgery.

Some patients need more imaging tests to help the doctors determine the stage of the cancer. A patient may need a CT scan, MRI, or CT/PET scan.

The stage of the cancer is determined by where it appears. The following summarizes the stages:

  • Local: Skin only.
  • Nodal: Skin and lymph nodes.
  • Metastatic: Cancer has spread beyond the skin and lymph nodes to other areas of the body.


The patient’s stage plays an important role in the treatment plan. The doctors also consider the patient’s age, overall health, and personal preferences. A treatment plan for MCC will consist of one or more of these treatments:

  • Surgery to remove the tumor.
  • Surgery to remove lymph nodes.
  • Radiation treatments.
  • Chemotherapy.
  • Clinical trial.


Excision (surgery): During this surgery, the surgeon removes the tumor and some surrounding tissue that looks healthy. Removing healthy looking tissue helps to catch cancer that may have traveled to an area that still looks healthy. An area can look healthy if it contains just a few cancer cells.

Mohs surgery: Because MCC often develops on the face and other areas with little fat, Mohs (pronounced "Moes") surgery may be recommended. This specialized surgery is used only to treat skin cancer. This surgery allows the Mohs surgeon to remove less healthy looking tissue.

During Mohs surgery, the Mohs surgeon cuts out the tumor plus a very small amount of healthy looking tissue surrounding the tumor. While the patient waits, the Mohs surgeon uses a microscope to look at what was removed. The surgeon is looking for cancer cells.

If the Mohs surgeon finds cancer cells in the healthy looking tissue, the surgeon will remove another small amount of healthy looking tissue and look at it under the microscope. This process continues until the surgeon no longer sees cancer cells.

MCC can grow deep, so some patients need reconstructive surgery. This surgery is usually performed immediately after the cancer surgery.

Lymphadenectomy: This is surgery to remove lymph nodes. This surgery is also called lymph node dissection.

Radiation treatments: This is often part of the treatment plan for MCC because this cancer has a high risk of returning after surgery. Studies show that radiation treatments reduce the risk of MCC returning. Patients usually begin radiation treatments within 4 weeks of having surgery to remove the cancer.

Radiation treatments also are given to patients who cannot undergo surgery. Findings from a study suggest that radiation alone can be an effective treatment.

Some patients receive radiation treatments to help them feel more comfortable. Your doctor may refer to this as palliative therapy. This therapy does not treat the disease. It helps people feel better.

Most patients receive radiation treatments in a hospital or outpatient facility. The treatments are usually given 5 days a week, Monday through Friday, for 5 weeks.

Chemotherapy: Doctors recommend chemotherapy for some patients who have MCC that has spread beyond the skin and lymph nodes. Chemotherapy treats the cancer with drugs that can kill the cancer cells.

Clinical trial: Some patients are encouraged to join a clinical trial. A clinical trial is a type of research study. This study tests how well new a treatment or a new way of treating a disease works. For some patients joining a clinical trial may be the best treatment option.

What is the outcome for patients with MCC?

MCC is an aggressive cancer. It can return after treatment. It often returns within the first 6 to 12 months after diagnosis. For this reason, it is essential to keep all follow-up appointments with your doctors.

On a positive note, findings from a research study show that patients who do not have cancer in their lymph nodes have an excellent prognosis (outcome). Patients who have stage I, II, or III MCC tend to do better than patients who have MCC that has spread beyond the lymph nodes.

Every patient treated for MCC needs to keep all follow-up appointments.


References:
Allen PJ, Bowne WB, Jaques DP, et al. “Merkel cell carcinoma: Prognosis and treatment of patients from a single institution.” J Clin Oncol. 2005; 23:2300-9.
Bichakjian CK, Alam M, Andersen J et al. “Merkel cell carcinoma: Clinical practice guidelines in oncology.” National Comprehensive Cancer Network. Version 2.2013.
Colgan MB, Tarantola TI, Wearver AL et al. “The predictive value of imaging studies in evaluating regional lymph node involvement in Merkel cell carcinoma.” J Am Acad Dermatol. 2012; 67:1250-6.
Hawryluk EB, O'Regan KN, Sheehy N, et al. “Positron emission tomography/computed tomography imaging in Merkel cell carcinoma: a study of 270 scans in 97 patients at the Dana-Farber/Brigham and Women's Cancer Center.” J Am Acad Dermatol. 2013; 68:592-9.
Howle JR, Hughes TM, Gebski V et al. “Merkel cell carcinoma: an Australian perspective and the importance of addressing the regional lymph nodes in clinically node-negative patients.” J Am Acad Dermatol. 2012; 67:33-40.
Pape E, Rezvov N, Penel N, et al. “Radiotherapy alone for Merkel cell carcinoma: a comparative and retrospective study of 25 patients.” J Am Acad Dermatol 2011; 65:983-90.
Tarantola TI, Vallow LA, Halyard MY, et al. “Prognostic factors in Merkel cell carcinoma: Analysis of 240 cases.” J Am Acad Dermatol. 2013; 68:425-32.
Tarantola TI, Vallow LA, Halyard MY, et al. “Unknown primary Merkel cell carcinoma: 23 new cases and a review.” J Am Acad Dermatol. 2013 68:433-40


Merkel cell carcinoma: Tips for managing

Findings from research studies suggest that patients treated for Merkel cell carcinoma (MCC) should:

1. Keep all follow-up appointments with your doctors. MCC is an aggressive skin cancer. It can return after treatment. For this reason, doctors who have expertise in treating MCC recommend:

  • Every patient treated for MCC needs a follow-up visit every 3 to 6 months for the first 2 years.
  • After 2 years of cancer-free exams, the patient should return every 6 to 12 months for a complete exam.
  • Each exam should include a complete skin exam and an exam of certain lymph nodes.


These follow-up visits help find skin cancer in the earliest stage. The sooner the cancer is found and treated, the better the outcome.

2. Perform skin self-exams as often as your dermatologist recommends. If you have received treatment for MCC, it is essential that you learn how to perform a skin self-exam. Your dermatologist or someone in your dermatologist’s office can teach you exactly what you need to know, including how to examine certain lymph nodes.
3. Protect your skin from the sun. If you have had MCC, you must always protect your skin from the sun. The sun’s rays damage skin. Your dermatologist can offer you specific tips that meet your needs.

4. Ask your doctors what else you can do to improve your outcome. Some doctors recommend eating a healthy diet and exercising to keep the immune system strong. Getting enough sleep also is important. Be sure to ask your doctors what could help you.

Related resources:


References:
Akhtar S, Oza KK, Wright J. “Merkel cell carcinoma: report of 10 cases and review of the literature.” J Am Acad Dermatol 2000 Nov; 43(5 Pt 1):755-67.
Bichakjian CK, Alam M, Andersen J, et al. “Merkel cell carcinoma: Clinical practice guidelines in oncology.” National Comprehensive Cancer Network. Version 2.2013.
Gao L. “Merkel cell carcinoma: Tips and advancements in management.” Educational session presented at the 2013 American Academy of Dermatology Annual Meeting: Miami. Mar 2013.


© 2020 American Academy of Dermatology. All rights reserved. Reproduction or republication strictly prohibited without prior written permission. Use of these materials is subject to the legal notice and terms of use located at https://www.aad.org/about/legal

Location

Integrative Dermatology & Laser Spa
3919 W Jefferson Blvd. , Ste. 200
Fort Wayne, IN 46804
Phone: 260-450-1313
Fax: 855-583-3606

Office Hours

Get in touch

260-450-1313